Chronic pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage (IASP, 2012).
Although traditional medication such as NSAID, opiods or anti-depressants are viable treatment options for chronic pain patients, there is still a significant proportion of patients with no or inadequate response to analgesics.
Therefore, the identification of novel pain mediators could open opportunities for new medicine, which may result in improved analgesic treatment for many patients.
WP1 aims to use high throughput technologies in order to identify novel pain mediators in tissue from both animal models and clinical samples.
To understand the pathophysiological mechanisms underlying chronic pain using optimized animal models of chronic pain developed in collaboration with other WPs such as WP2 & WP3