WP4  summary:

Workpackage 4 will study different types of chronic pain. One arm of this WP will evaluate new and objective ways of measuring pain, which is much needed. We will use methods to measure signals in single pain nerve fibers (microneurography), Magnetic brain scans (arterial spin labeling and Resting State Network) in chronic pain patients and compare to reported symptoms. A second arm will use pain descriptors (such as questionnaire results and specific examination results) specific for different chronic pain states, and develop them as a tool for setting the right diagnose. Today, there are no simple blood samples or alike to give the right diagnosis, and so called biomarkers will be sought after. It is believed that men and women as well as people of different ages react differently to pain, and this will also be investigated. Any genetic or inborn traits, mental or psycho-social factors predisposing for chronic pain will also be investigated. The probability of having a pain relieving effect of drug treatment based on specific signs and symptoms is being investigated in a randomized controlled trial. Placebo effects play a great role in the response to pain treatment, both in clinical drug trials and in the everyday clinical world. Mechanisms of importance to placebo effects will be investigated. A better understanding of placebo effects will improve the design and performance of clinical trials, giving more reliable results, and eventually result in better treatments for patients