The main goal of work package 6 is to extend already existing databases and integrate data from consortium database resources and other data being generated by other work packages (WP 1, 3, 4 and 5).
There are already well established databases within the consortium, the London Pain Database (LPD) and QUAST (DFNS, Germany): The LPD is used for datamining of functional genomics data to help identify individual genes and functional networks associated with chronic pain, QUAST on the other hand collects questionnaire data, clinical and neurophysiological findings and calculates valid clusters of phenotypes with different interaction patterns of sensory loss with and without different types of peripheral and central hyperalgesia based on QST (quantitative sensory testing) data.
Meanwhile NeuroQUAST (see fig. 1), a programme specifically fitted for the needs of EUROPAIN was developed and distributed among the participating centers to collect the clinical and questionnaire, as well as QST data (see fig. 2). Monthly, NeuroQUAST exports are sent from the participating centers to the database manager, who reports back detailed feedback about the current number of collected data sets and blood samples in a monthly newsletter (see fig. 3).
Finally, the genomic and proteomic analysis conducted from the blood samples collected within WP4 will be matched with the corresponding well-defined phenotypic data integrated in NeuroQUAST.
Fig. 1: NeuroQUAST
Fig. 2: NeuroQUAST QST result
Fig. 3: Monthly newsletter